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Using Cannabis for Topicals Practices 5 Best

danielfox
01.07.2018

Content:

  • Using Cannabis for Topicals Practices 5 Best
  • The 101: The Ins And Outs Of Top(Icals)
  • Introduction
  • Thinking about adding cannabis topicals to your wellness regimen? Here are five best practices to keep in mind so you can get the most out of this infused. It's time to rub, rub, rub it in, and try the world of cannabis-infused lotions Get started with Leafly's 5 Best Practices for using cannabis topicals. You've probably heard that cannabis topicals are great for your skin, but did years ago in India where cannabis was incorporated into tantric sex practices. And unlike other antibiotics, using cannabis does not lead to the growing “All five major cannabinoids tested (cannabidiol, cannabichromene.

    Using Cannabis for Topicals Practices 5 Best

    As we age, our ECS produces fewer endocannabinoids; they may also decrease due to physical injury or disease. Replenishing depleted endocannabinoids with phytocannabinoids like CBD can help restore balance to the body.

    As a rule, CBD oil extracted from hemp will contain no more than 0. CBD oils extracted from hemp generally fall into one of the following three categories: The vast majority of CBD oils come in bottles measuring either 15 milliliters mL , or 0.

    However, CBD concentration is more important than bottle size. Concentration refers to the ratio of hemp oil solution measured in mL compared to the amount of CBD cannabinoid measured in milligrams, or mg.

    A mL bottle may contain mg of CBD, mg, mg, or more. The higher the mg amount, the stronger the CBD oil will be. How much CBD oil you should take largely depends on your bodyweight, as well as the desired effects. The next table breaks down the effects of different doses based on these two factors.

    Always consult your physician to determine the best dosage for you. CBD oil alleviates physical pain and anxiety — both of which can have a negative impact on sleep. Additionally, CBD oil can actually prolong sleep for some, leading to more rest from night to night. However, please note that the medicinal effects of CBD oil have not been studied extensively. While many medical patients claim the oils improve sleep quality and duration, more clinical trials are needed to determine how and why these improvements occur — and if they are applicable to all individuals.

    Additionally, CBD oil is also associated with some negative side effects. CBD oil is considered therapeutic and low-risk for most users. However, CBD oil may result in the following adverse effects: This may be the desired effect. In recent years, the legality of CBD oil and other products derived from hemp or marijuana has been a hot-button issue. Historically, hemp could legally be grown and cultivated for academic research purposes only.

    However, the legality of hemp growth has changed in the past year. In April , Sen. Mitch McConnell of Kentucky introduced the Hemp Farming Act of , a piece of legislation that proposed legalizing all hemp products at the federal level.

    Per the farm bill, industrial hemp will be descheduled as a federally controlled substance. Still, the legality of marijuana-based CBD oil also varies from state to state.

    The table below lists general guidelines for hemp- and marijuana-based CBD oil consumption based on different state laws. These states have more complex laws pertaining to hemp- and marijuana-based CBD oils. These initiatives may have a bearing on the legality and availability of CBD oils. Three other states, Arizona, Missouri, and Nebraska, failed to garner enough votes to place marijuana initiatives on the ballots.

    These laws are ever-changing, and the guidelines listed above should not substitute for legal advice. When purchasing hemp-derived CBD oil for sleep, you may be able to find products through one or more of the following establishments: Cost is another consideration.

    Most CBD oils are sold in concentrations of to mg, although this may range from less than mg to more than 2, A good indicator of price-point is the cost per milligram. Low-cost CBD oils usually fall between five and 10 cents per mg; mid-range prices are 11 to 15 cents per mg; and higher-end oils cost 16 cents per mg or higher.

    Although price may be an indicator of CBD oil quality, we suggest researching the following factors to ensure the oil you select is considered high-quality. Some forms of CBD oil — such as vapors and tinctures — normally have higher-than-average concentrations, whereas sprays and topicals tend to have lower concentrations. When buying CBD oil for the first time and comparing different products, here are a few variables to keep in mind: As noted in the previous section, CBD oil prices vary significantly by brand.

    The best practice for most is to determine a per-milligram budget for CBD oil, as well as a maximum price for the entire bottle. Also, if ordering online, be sure to include potential shipping costs.

    Weight plays a role in the effects of CBD oil, and bottle size should be selected based on how much you weigh. If you weigh more than pounds and desire strong effects, then this same concentration will supply roughly 10 doses. Also, state residence may indicate that fewer buying locations are available. If the answer is yes, then full spectrum CBD oils may not be a feasible option due to their THC content; although these oils contain trace amounts of THC, this may lead to a failed drug test.

    Crystalline isolate oils, on the other hand, contain no THC and will not compromise drug tests in any way. Third-party testing information is vital for consumers; any CBD oils that do not supply these details should be avoided. Lab results are not as crucial, but may indicate a higher-quality product if they are included. Both online and brick-and-mortar experiences carry pros and cons for CBD oil shoppers. In addition to natural, unscented CBD oils, many oils come in different flavors.

    This factor boils down to personal preference — although the flavor selection will be broader with some brands than others. How Does Marijuana Affect Sleep? This research is supported by you, our readers, through our independently chosen links, which earn us a commission. Crystalline Isolate Oil is extracted from cannabis plant, then allowed to cool; this isolates the CBD from other cannabinoids The oil forms crystals and is crushed into a powder None White and twinkly No Full Spectrum Oil Oil is extracted from the cannabis plant Oil is not cooled, allowing it to retain THC and other cannabinoids 0.

    CBD oil can be consumed in several different ways. CBD oils may be manufactured as small capsules that are orally ingested. Another form of oral CBD oil ingestion is the tincture, often used as a food additive. Tinctures are sold in dropper bottles; most users place one or two drops beneath their tongue for several minutes in order to experience the full effects.

    Tinctures normally have stronger concentrations compared to other CBD products. CBD oil can be ingested as an oral spray. Sprays tend to have lower concentrations compared to other CBD products. This form of CBD oil is applied directly to the skin; it usually has the consistency of lotion. Weight Group Recommended Dosage for Mild Effects Recommended Dosage for Moderate Effects Recommended Dosage for Strong Effects Light less than pounds 11 mg or less 12 to 14 mg 15 to 17 mg Medium to pounds 18 mg or less 15 to 23 mg 18 to 28 mg Heavy more than pounds 23 mg or less 24 to 30 mg 29 to 45 mg.

    The anxiety-alleviating and sleep-prolonging qualities of CBD oil make it a good option for many people with insomnia. Those who experience insomnia due to pain or discomfort may also find that using CBD oil alleviates their physical symptoms to a noticeable extent.

    CBD oil may also promote daytime wakefulness when taken in small amounts; people with insomnia can use it as a pick-me-up if they feel excessively tired due to lack of restful sleep. REM behavior disorder RBD is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep.

    Both depression and anxiety disorder have been linked to sleep disruption. CBD oil can alleviate symptoms of these disorders because it activates serotonin receptors in the brain; the release of serotonin has soothing, anti-anxiety effects that can help people sleep. CBD oil also increases levels of adenosine in the brain; adenosine is a neurotransmitter that aids cardiovascular function and eases painful inflammation.

    CBD oil may be prescribed for patients with Lennox-Gastaut syndrome or Dravet syndrome, two rare forms of severe epilepsy; the medication Epidiolex, a CBD oil oral solution, is typically prescribed in these instances. CBD oil can also ease the severity of seizures for people with other forms of epilepsy.

    Due to its anti-psychotic effects, non-THC CBD oil can reduce the symptoms of schizophrenia and other disorders with psychotic effects. The liver regulates the way different drugs are metabolized within the body; this process is known as hepatic drug metabolism. Higher-than-average doses of CBD oil can slow the hepatic drug metabolism process. As a result, users may not be able to process other drugs as quickly.

    This is particularly concerning for CBD oil users who also take prescription medications. As is the case with many other hemp- and marijuana-based products, CBD oil often leads to a condition known as dry mouth or cottonmouth. This is likely due to cannabinoids altering receptors in the lower jaw that trigger salivation.

    In most cases, mild discomfort and stronger-than-average thirst are the only issues associated with dry mouth. CBD oil may incite a small drop in blood pressure immediately after it is consumed; this may also cause the user to feel lightheaded.

    Diarrhea is a common side effect for people who take relatively large doses of CBD oil, and is linked to the substance interacting with the digestive system.

    Lowering oil doses often minimizes this effect. CBD oil may make users feel hungrier than usual, which is a common effect of most cannabinoids. Marijuana-based CBD oils are illegal to use recreationally or for medical reasons.

    The state senate recently introduced legislation that would legalize CBD oil, but the governor struck down this motion. Marijuana-based CBD oil is illegal to use recreationally, but is available to medical patients participating in a clinical trial. Hemp-based CBD is legal. Marijuana-based CBD oil is illegal to use recreationally, but is legal for research purposes when used to treat epilepsy. Anecdotal reports to us from patients who routinely smoke or vaporize cannabis containing varying amounts of thc and cbd before chemotherapy confirm improvement in their quality of life as measured by the Edmonton Symptom Assessment System and subsequent appetite and food intake.

    Although treatment of some specific body areas abdomen, chest, whole brain with radiotherapy can induce nausea, very few reports of cannabinoid use in those situations have been published, and the reports that exist have used mainly pharmaceutical cannabinoids A recently published placebo-controlled study demonstrated that quality of life for patients with head-and-neck cancers undergoing radiotherapy is not improved with the use of nabilone The authors postulated that nabilone on its own is not potent enough to affect symptoms.

    Another recently published study surveyed 15 patients with previously treated head-and-neck cancer about their use of medical cannabis, and all respondents endorsed the benefits of cannabis in the treatment of the long-term residual effects of radiation The data supporting cannabis and cannabinoid use in appetite stimulation is less conclusive than it is in pain or nausea.

    When used in cancer patients with cachexia, cannabinoids appear to be only modestly effective. A study from the North Central Cancer Trial Group compared the use of an oral cannabinoid dronabinol with oral megestrol acetate and with the two drugs together.

    Final results did not show any statistical improvement in weight with dronabinol, either alone or in combination A Swiss-led study using cannabis extract in cancer patients also did not show benefit in terms of appetite or weight gain, and the trial was closed early after a mandated review A small Canadian study using oral dronabinol in advanced cancer patients demonstrated improved sense of taste and subsequent increased protein consumption.

    That change did not translate to weight gain, but patients did express improvement in quality of life measurements More promising results were seen in studies of the non-cancer population.

    A study of response to smoked cannabis, dronabinol, or placebo in patients with aids demonstrated that the patients using smoked cannabis experienced the greatest weight gain 3. An earlier study in patients with dementia treated with either dronabinol or placebo documented an increase in appetite, increased weight gain, and modulated aggressive behaviour Although the main use of cannabinoids in patients with cancer and palliative patients has been symptom management, there could be other roles for these molecules in the treatment of malignancies.

    In one of the first reports of cannabinoids having antitumour effects, extracts of cannabis were shown to inhibit the growth of lung adenocarcinoma cells in vitro An in vivo mouse model produced similar results. Preclinical studies have investigated cannabinoid activity in several malignancies lung, glioma, thyroid, lymphoma, skin, pancreas, endometrium, breast, prostate 59 — 61 , demonstrating antiproliferative, anti-metastatic, antiangiogenic, and proapoptotic effects reviewed by Velasco et al.

    Cannabis has not been studied clinically as a treatment for malignancy. The only clinical study published to date that used cannabinoids enrolled patients with glioblastoma multiforme and was based on extensive preclinical work by the same investigators Their small study 9 patients showed the safety of intracranial administration of thc and demonstrated antiproliferative effects in some of the patients.

    All patients eventually progressed and died, but not because of any effects of the extract. The investigators are actively continuing their clinical and research work, focusing on tumours of the central nervous system Oncologists might be concerned that cannabinoids could reduce the effectiveness of established chemotherapy agents. Several authors have investigated cannabis extracts used in tandem with a variety of chemotherapy agents in vitro and in animal models, showing synergism in reducing cell numbers, and no negative effect on anticancer function.

    Cell cultures from pancreatic 64 , glioma 65 , gastric 66 , lung 67 , and colon 68 cancers have been investigated using a range of antineoplastic agents, including gemcitabine, temozolomide, paclitaxel, and 5-fluorouracil.

    Synergism in inducing cancer cell death is a common finding, which bodes well for the possibility of human clinical trials in future Despite the emerging evidence of antineoplastic activity, some older in vitro studies demonstrated cancer cell proliferation and loss of immune-mediated cancer suppressor activity after treatment with cannabinoid preparations 58 , Some studies have even shown discordant results depending on the concentration of cannabinoids: Thus, conflicting evidence points to the need for sober second thought before outright recommendations of cannabinoids for cancer patients can be made.

    But again, mice and rats are not people, and what is observed in vitro does not necessarily translate into clinical medicine. The preclinical evidence that cannabinoids might have direct anticancer activity is provocative as well, but more research is warranted.

    Currently, several clinical studies using cannabinoids in cancer therapy are registered at http: When a patient is referred to our outpatient clinic with a request for medical cannabis, several questions come to mind:.

    Most of our patients have either tried medical cannabis or read about its role in symptom control. Those who have tried it recreationally or for medical purposes can accurately reflect on the benefits or the adverse effects experienced, which makes the discussion somewhat easier. Those who have little knowledge and less experience require a complete discussion with respect to the benefits, the possible adverse effects, the process of application and authorization, and the cost which is borne by the patient, because it is not covered by provincial or private medical insurance.

    Table iii lists our contraindications to authorization, which are similar to those published by Health Canada 70 , the College of Family Physicians of Canada 71 , and the Canadian Medical Protective Association It should be noted that no special license or additional certification is necessary to authorize the use of medical cannabis, but a working knowledge of cannabis as already presented is helpful for oncology professionals who are considering a patient request.

    Once the decision is made to support authorization, the choice of which licensed producer and product to use can be somewhat difficult for some patients. The more than 30 licensed producers list more than products for sale, which can be a problem for those who do not have experience with cannabis or patients who might be elderly or excessively fatigued.

    We do not advise that patients smoke the dried product; rather, they should vaporize, which is likely safer in the long run We also advise neophytes to choose a product that has a balanced thc: Cannabinoid proportions can be guided by available efficacy data summarized in Table iv. Once patients have started to use the product and document the effects, the thc: Conditions potentially responding to cannabinoid therapies 74 — Titration of dose should follow the effect on the symptom in question for example, pain reduction, nausea control.

    Follow-up with patients is essential to determine benefits and any adverse effects, questions about use or strain selection, and outcomes. Certainly, if the adverse effects are not tolerable, then an alternative therapy should be considered. If the patient is not getting the desired symptom control, then some dose modification might be necessary. Discontinuation of cannabis should be considered if an adequate trial does not result in the desired outcome as determined by the treating team or the patient.

    Inter-professional collaboration is the new paradigm under which modern health care operates Research has demonstrated that inter-professional collaboration is enabled and promoted by inter-professional education, especially at the undergraduate level 79 , Although physicians ultimately authorize and prescribe cannabinoid therapies, valuable insights and inputs about achieving optimal patient outcomes can be derived from other members of the health care team, including nurses, social workers, rehabilitation therapists, and pharmacists.

    Furthermore, pharmacies are designed to ensure proper storage and security of medical products. Pharmacists are also well positioned to comprehensively counsel patients and caregivers on the optimal methods of opioid and by extension, cannabis storage and disposal so as to limit diversion and unintentional exposure Moreover, given the emergence of cannabinoids as a novel therapeutic class, cannabinoid education for medical professionals as well as for patients and caregivers should be conducted per the principles of inter-professional education Industrialized countries are experiencing exponential increases in the utilization of opioids 84 , Major public health issues are emerging as a result, not the least of which relate to drug diversion, opioid addiction, and death from opioid overdose 84 , Currently, opioids remain the mainstay of cancer pain management, and increased cancer survival translates into patients using opioids for longer periods of time High-dose and long-term opioid therapy in cancer patients is becoming a concern, given observed risks such as poly-endocrinopathy, osteoporosis, and immunosup-pression Preclinical studies have demonstrated that certain opioids—such as codeine, morphine, methadone, and remifentanil—are associated with increased morbidity and mortality attributable to worsening of cancer and infections Opioid-induced hyperalgesia syndrome is also being reported with increased incidence, especially in patients with advanced cancer and escalating pain Thus, it behooves physicians to explore options that will allow for improved overall pain relief while curbing the overuse of opioids.

    Observational studies in advanced cancer cohorts have demonstrated that cannabinoid therapies are associated with opioid-sparing and improved analgesia Published data on the addiction potential for recreational cannabis reflects a risk of 9.

    Finally, a British study showed that the overall harm score for user and society for recreational cannabis score: Because medical cannabis generally tends to have a higher ratio of cbd to thc , it would be expected to be associated with a lower predilection to diversion, less addiction potential, and lower overall harm scores than those for recreational cannabis The integration and broader utilization of cannabinoid therapies within the domain of oncology including palliation carries the potential not only for improved health care outcomes for patients but also for economic savings and greater safety for society 90 , Patient reports of improvement in quality of life, especially for those undergoing intensive treatment regimens, could be key to patients continuing with lifesaving or life-prolonging therapies.

    Cannabinoids might be able to help patients throughout their disease trajectory, but evidence about the ideal timing for cannabinoid initiation is lacking. More research will guide oncology and palliative care teams in their pursuit of excellence in cancer and symptomatic care. VM has presented educational activities supported by Tweed, Bedrocan, and Mettrum.

    National Center for Biotechnology Information , U. Journal List Curr Oncol v. Published online Dec Find articles by P. Author information Copyright and License information Disclaimer. Copyright Multimed Inc. This article has been cited by other articles in PMC. The Endocannabinoid System The endogenous opioid and cannabinoid systems are the only chemical systems in the human body that have survived more than million years of human evolution 1 — 4.

    Cannabinoid Pharmacology In Canada, more than strains of medical cannabis are available from licensed producers 5. Open in a separate window. Cannabinoids for Medical Use Although the assessment and treatment of pain and other symptoms in patients with advanced cancers has become a standard of care, many patients still have incomplete symptom control Pain Cannabinoids, including herbal cannabis and extracts, have been used for the treatment of pain for centuries. Nausea and Vomiting Controlling nausea and vomiting was one of the initial uses of cannabinoids documented in the modern scientific literature.

    Appetite Stimulation The data supporting cannabis and cannabinoid use in appetite stimulation is less conclusive than it is in pain or nausea. The Importance of Inter-professional Collaboration Inter-professional collaboration is the new paradigm under which modern health care operates Cannabinoid Therapies As a Harm Reduction Strategy Industrialized countries are experiencing exponential increases in the utilization of opioids 84 , Oxford University Press; The Medicinal Uses of Cannabis and Cannabinoids.

    Grotenhermen F, Russo E, editors. Pharmacology, Toxicology, and Therapeutic Potential. The Haworth Therapeutic Press; Medical cannabis in the palliation of malignant wounds—a case report.

    J Pain Symptom Manage. Programming of neural cells by endo cannabinoids: Endocannabinoid signaling at the periphery: Cannabinoid receptors and their ligands: Cannabinoids for symptom management and cancer therapy: J Natl Compr Canc Netw. Mitochondrial cb 1 receptors regulate neuronal energy metabolism. A critical review of the antipsychotic effects of cannabidiol; 30 years of a translational investigation. Zhornitsky S, Potvin S.

    Cannabidiol in humans—the quest for therapeutic targets. Pharmaceuticals Basel ; 5: Romano LL, Hazekamp A. Pharmcokinetics and pharmacodynamics of cannabinoids. The pharmacology of cannabinoid receptors and their ligands: Int J Obes Lond ; 30 suppl 1: Cytochrome P enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.

    Identification of cytochrome P enzymes responsible of cannabidiol by human liver microsomes. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: Interindividual variation in the pharmacokinetics of delta9-tetrahydrocannabinol as related to genetic polymorphisms in CYP2C9. Pharmacokinetic drug interactions with tobacco, cannabinoids and smoking cessation products.

    Probable interaction between warfarin and marijuana smoking. American Society of Clinical Oncology provisional clinical opinion: Survey of Australians using cannabis for medical purposes.

    Integrating cannabis into clinical cancer care. Cannabis potency and contamination: Invasive pulmonary aspergillosis associated with marijuana use in a man with colorectal cancer. Cannabis smoking and respiratory health: Cannabinoid dose and label accuracy in edible medical cannabis products. Why I chose to use cannabis. Lynch M, Campbell F. Cannabinoids for treatment of chronic, non-cancer pain: Brit J Clin Pharmacol.

    Lynch M, Ware MA. Cannabinoids for the treatment of chronic non-cancer pain: Are cannabinoids a safe and effective treatment option in the management of pain? A qualitative systematic review. Evaluation of intramuscular levonantradol and placebo in acute postoperative pain. Effects of nabilone, a synthetic cannabinoid, on postoperative pain.

    Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of thc: Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: Inhaled cannabis for chronic neuropathic pain: N Engl J Med.

    Cannabinoids for control of chemotherapy induced nausea and vomiting: Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: Eur J Cancer Care Engl ; Deltatetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation.

    The 101: The Ins And Outs Of Top(Icals)

    Topical cannabis is great, and comes in the form of the label for information about the appropriate amount of product to use for your condition. An emerging batch of cannabis-laced pain relievers and skin smoothers who is currently developing methods for nanoparticle delivery of CBD through the skin. using contains high-quality cannabinoids, the best bet is to buy from a combines CBD and THC in a five-to-one ratio to diminish discomfort. Cannabis topicals are a great way to enjoy the benefits of THC and CBD without consuming cannabis. They're useful for a variety of peo.

    Introduction



    Comments

    leontiev

    Topical cannabis is great, and comes in the form of the label for information about the appropriate amount of product to use for your condition.

    ASDF4561

    An emerging batch of cannabis-laced pain relievers and skin smoothers who is currently developing methods for nanoparticle delivery of CBD through the skin. using contains high-quality cannabinoids, the best bet is to buy from a combines CBD and THC in a five-to-one ratio to diminish discomfort.

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